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C4d – RMab

SKU: 5fb73d063643 Categories: , , ,

IHC of C4d on an FFPE Spleen Tissue

Specification Sheets
Safety Data Sheet

SDS

Intended Use For In Vitro Diagnostic Use
Summary and Explanation

Complement component 4, or C4, plays a central role in the complement system. C4d is the final proteolytic remnant of deposited C4b on endothelium and remains covalently attached to endothelium for little more than a week. It is easily detectable by Immunohistochemistry. Anti-C4d combined with anti-C3d can be utilized as a tool for diagnosis of AR (Acute Rejection) and warrant prompt and aggressive anti-rejection treatment. C4d can be detected in peritubular capillaries in both chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival and is an aid in treating acute rejection.

Antibody Type Rabbit Monoclonal Clone EP273
Isotype IgG Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous Control Tonsil, Lymph Node, Spleen, Kidney, Kidney Transplant Rejection
Presentation C4d is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Availability
Catalog No. Antibody Type Dilution Volume/QTY
BSB 2831 Prediluted Ready-To-Use 3.0 ml
BSB 2832 Prediluted Ready-To-Use 7.0 ml
BSB 2833 Prediluted Ready-To-Use 15.0 ml
BSB 2834 Concentrated 1:50-1:200 0.1 ml
BSB 2835 Concentrated 1:50-1:200 0.5 ml
BSB 2836 Concentrated 1:50-1:200 1.0 ml
BSB 2837 Control Slides 5
Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product.

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